Superantigens are bacterial proteins that stimulate the immune system much more extensively than do normal antigens. They stimulate T-cells to proliferate nonspecifically through simultaneous interaction with class II MHC proteins on antigen-presenting cells and variable regions on the b chain of the T-cell receptor complex. Examples include streptococcal scarlet fever toxins, staphylococcal toxic shock syndrome toxin-1, and streptococcal M protein.

Microbiology. . 2009.

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